Description

Chloropyramine Hydrochloride is a potent, first-generation H1-antihistamine compound widely utilized in pharmaceutical research and development. Its primary value lies in its well-characterized mechanism of action, serving as a critical reference standard and active pharmaceutical ingredient (API) for developing anti-allergic and antipruritic medications. This compound is essential for pharmaceutical manufacturers, research institutions, and analytical laboratories focused on allergy, immunology, and dermatology applications. Rigorous quality control ensures its suitability for high-stakes formulation and analytical work.

Application

• Pharmaceutical API: Serves as the active ingredient in the formulation of anti-allergy and antipruritic (anti-itch) medications.
• Reference Standard: Used in analytical laboratories for quality control, method validation, and calibration in HPLC, UV, and other spectroscopic assays.
• Biochemical Research: A key tool for studying histamine H1-receptor antagonism, allergic response pathways, and inflammatory processes.
• Veterinary Medicine: Employed in the development of treatments for allergic conditions in animals.
• Dermatological Preparations: Incorporated into topical creams or ointments for managing skin allergies and urticaria.
• Academic & Clinical Research: Facilitates pharmacological studies and clinical trials related to antihistamine efficacy and safety profiles.

Basic Information

Product Name	Chloropyramine Hydrochloride
CAS No.	6170-42-9
Molecular Formula	C16H21ClN3·HCl
Molecular Weight	324.27 g/mol
Synonyms	Chloropyramine HCl; Halopyramine; Synopen; Chloropyraminum; N-(4-Chlorobenzyl)-N',N'-dimethyl-N-pyrimidin-2-ylethane-1,2-diamine Hydrochloride; 1-(4-Chlorobenzyl)-2-(pyrimidin-2-ylamino)-N,N-dimethylethanamine Hydrochloride; Suprastin (related analogue); Chlorpheniramine analogue
EINECS	228-222-8

Quality Control

Our Chloropyramine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) documenting results for assay, related substances, residual solvents, and microbiological attributes is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Meets Ph. Eur. criteria for non-sterile substances

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.