Description

Cyproheptadine Hydrochloride is a first-generation antihistamine and serotonin antagonist of the piperidine class. This compound is a critical active pharmaceutical ingredient (API) valued for its precise pharmacological activity in therapeutic formulations. It is primarily required by pharmaceutical manufacturers and research institutions for the development and production of prescription medications targeting allergic conditions and appetite stimulation.

Application

• Pharmaceutical API: Core active ingredient in prescription antihistamine medications for treating allergic rhinitis, conjunctivitis, and mild allergic skin reactions.
• Appetite Stimulant: Used in formulations aimed at promoting weight gain and managing cachexia or appetite loss in clinical settings.
• Migraine Prophylaxis: Employed in some therapeutic regimens for the prevention of migraine headaches, leveraging its serotonin-antagonist properties.
• Veterinary Medicine: Applicable in veterinary pharmaceuticals for managing allergic conditions and as an appetite enhancer in animals.
• Biochemical Research: Serves as a reference standard and tool compound in pharmacological studies related to histamine H1-receptor and serotonin receptor antagonism.
• Generic Drug Manufacturing: Essential for the production of cost-effective generic versions of cyproheptadine-based drugs, ensuring wider accessibility.

Basic Information

Product Name	Cyproheptadine Hydrochloride
CAS No.	6032-06-0
Molecular Formula	C21H21N·HCl
Molecular Weight	323.86 g/mol (Hydrochloride salt)
Synonyms	Periacin; Periactin; Cyproheptadine HCl; 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine hydrochloride; MK-141; (1-Methyl-4-(5-dibenzo[a,e]cycloheptatrienylidene))piperidine hydrochloride; N-methyl-4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine hydrochloride; Antegan
EINECS	227-891-8

Quality Control

Our Cyproheptadine Hydrochloride is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to meet high-purity standards suitable for pharmaceutical applications, including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white, crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Solubility	Freely soluble in water and methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.