Description

Hydrocortisone Sodium Phosphate CAS NO 6000-74-4 is a water-soluble salt form of the naturally occurring glucocorticoid hormone hydrocortisone. This modification is critical for enhancing its bioavailability and stability in aqueous formulations, making it a preferred active pharmaceutical ingredient for injectable and ophthalmic solutions. It is primarily utilized by the pharmaceutical industry for the production of anti-inflammatory and immunosuppressive medications. Its reliable performance and high purity are essential for meeting stringent pharmacopeial standards in drug manufacturing.

Application

• Injectable Corticosteroid Formulations: As a key active ingredient in emergency injectable solutions for treating severe allergic reactions, adrenal insufficiency, and inflammatory conditions.
• Ophthalmic Solutions: Used in eye drops and ointments to reduce inflammation and treat conditions like uveitis and allergic conjunctivitis.
• Hospital Pharmacy Compounding: For the preparation of customized sterile preparations where rapid systemic effect is required.
• Topical Solution Concentrates: Serves as a base for compounding dermatological lotions and creams in specialized pharmacy settings.
• Veterinary Pharmaceutical Products: Employed in anti-inflammatory and shock therapy medications for animals.
• Research & Development: Used as a reference standard and biochemical reagent in pharmacological and endocrinological research.

Basic Information

Product Name	Hydrocortisone Sodium Phosphate
CAS No.	6000-74-4
Molecular Formula	C21H29Na2O8P
Molecular Weight	486.39 g/mol
Synonyms	Hydrocortisone 21-Phosphate Disodium Salt; Cortisol Sodium Phosphate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-(dihydrogen phosphate) disodium salt; Hydrocortisone 21-(Disodium Phosphate); EINECS 227-857-2; NSC 10483; A-hydroCort; Solu-Cortef (Brand Name Reference)
EINECS	227-857-2

Quality Control

Our Hydrocortisone Sodium Phosphate is manufactured under strict quality management systems. It is tested to meet or exceed relevant pharmacopeial standards, including USP (United States Pharmacopeia) and EP (European Pharmacopoeia) monographs where applicable. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring full traceability and compliance for GMP-driven applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (Karl Fischer)	≤ 8.0%
pH (5% Solution)	7.5 - 8.5
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Bacterial Endotoxins	< 0.17 EU/mg (for injectable grades)
Sterility	Conforms to test (for sterile grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.