Description

Methyl 2,2-Difluoro-2-(Fluorosulfonyl)Acetate is a high-value fluorinated building block and reagent, recognized for its unique difluoroacetate and fluorosulfonyl functional groups. This compound is critical for introducing the difluoromethylene (CF2) moiety and sulfur(VI) fluoride groups into target molecules, enabling advanced synthesis in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists working on novel active ingredients, particularly in medicinal chemistry for protease inhibitor development and the synthesis of sophisticated fluorinated intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of protease inhibitors and other bioactive molecules containing difluoromethylene ether or sulfonate ester linkages.
• Agrochemical Synthesis: Used in creating advanced fluorinated pesticides and herbicides, where the CF2 group enhances metabolic stability and bioavailability.
• Sulfur(VI) Fluoride Exchange (SuFEx) Click Chemistry: Serves as a reactive hub for SuFEx reactions, facilitating the rapid and reliable construction of polysulfates and sulfonates.
• Fluorinated Material Precursor: Employed in the research and development of specialty polymers and materials with tailored surface properties and chemical resistance.
• Organic Synthesis Reagent: Utilized as an electrophilic difluoromethylating agent or a source of the -SO2F group in complex multi-step synthetic routes.

Basic Information

Product Name	Methyl 2,2-Difluoro-2-(Fluorosulfonyl)Acetate
CAS No.	680-15-9
Molecular Formula	C3H3F3O4S
Molecular Weight	192.11 g/mol
Synonyms	Methyl Difluoro(fluorosulfonyl)acetate; Difluoro(fluorosulfonyl)acetic Acid Methyl Ester; Methyl 2,2-Difluoro-2-fluorosulfonylacetate; Acetic acid, 2,2-difluoro-2-(fluorosulfonyl)-, methyl ester; 680-15-9; Methyl difluorosulfonylacetate (common name)
EINECS	Contact for details

Quality Control

Every batch of Methyl 2,2-Difluoro-2-(Fluorosulfonyl)Acetate is produced and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original sealed packaging to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.