Description

2-Acetyl-3-Hydroxy-4,4,4-Trifluoro-3-(Trifluoromethyl)Butyric Acid Ethyl Ester is a high-value, multi-fluorinated organic building block. Its unique structure, featuring both acetyl and trifluoromethyl groups, makes it a critical intermediate for synthesizing complex molecules with enhanced properties. This compound is essential for research and production in advanced pharmaceutical and agrochemical development. It enables the introduction of fluorine atoms to improve metabolic stability, bioavailability, and lipophilicity in target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where fluorine substitution is required for efficacy and environmental persistence.
• Fluorinated Material Precursor: Serves as a monomer or intermediate for creating specialty polymers, coatings, and liquid crystals with unique thermal and chemical resistance.
• Organic Synthesis Reagent: A versatile reagent in academic and industrial R&D for constructing complex, fluorinated heterocycles and chiral molecules.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized fluorinated dyes and functional pigments.

Basic Information

Product Name	2-Acetyl-3-Hydroxy-4,4,4-Trifluoro-3-(Trifluoromethyl)Butyric Acid Ethyl Ester
CAS No.	680-09-1
Molecular Formula	C9H10F6O4
Molecular Weight	296.17 g/mol
Synonyms	Ethyl 2-Acetyl-3-hydroxy-4,4,4-trifluoro-3-(trifluoromethyl)butyrate; 4,4,4-Trifluoro-3-hydroxy-2-acetyl-3-(trifluoromethyl)butyric Acid Ethyl Ester; 2-Acetyl-3-hydroxy-4,4,4-trifluoro-3-trifluoromethylbutyric Acid Ethyl Ester; TFMB Ethyl Ester; 680-09-1; Butyric acid, 2-acetyl-3-hydroxy-4,4,4-trifluoro-3-(trifluoromethyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our 2-Acetyl-3-Hydroxy-4,4,4-Trifluoro-3-(Trifluoromethyl)Butyric Acid Ethyl Ester is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and high-purity research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.