Description

Tetraethylammonium Fluoride Dihydrate is a quaternary ammonium salt that serves as a versatile and highly effective source of fluoride ions in anhydrous organic synthesis. This compound is particularly valued for its dual role as a strong, non-nucleophilic base and a potent fluorinating agent, enabling critical transformations under mild conditions. It is an essential reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable fluorination chemistry.

Application

• Nucleophilic Fluorination Reactions: A key reagent for the synthesis of alkyl fluorides and aryl fluorides via SN2 and aromatic nucleophilic substitution mechanisms.
• Desilylation Agent: Efficiently cleaves silicon protecting groups (e.g., TBS, TMS, TES) in complex multi-step organic syntheses, particularly in pharmaceutical intermediate production.
• Promoter in Cross-Coupling Catalysis: Used as an additive to enhance the activity and stability of palladium catalysts in Suzuki, Stille, and Negishi cross-coupling reactions.
• Electrolyte Additive: Employed in the research and development of advanced battery systems, including lithium-ion and supercapacitors, to improve electrolyte stability and performance.
• Phase-Transfer Catalyst (PTC): Facilitates reactions between reagents in immiscible phases, useful in industrial-scale alkylation and polymerization processes.
• Biochemical Research: Utilized as an inhibitor of specific enzymes, such as cholinesterases, for mechanistic studies and diagnostic applications.

Basic Information

Product Name	Tetraethylammonium Fluoride Dihydrate
CAS No.	665-46-3
Molecular Formula	C8H20FNO2 or (C2H5)4N·F·2H2O
Molecular Weight	181.25 g/mol (anhydrous basis)
Synonyms	TEA Fluoride Dihydrate; Tetraethylammonium Fluoride Hydrate; TEF; Et4NF·2H2O; N,N,N-Triethylethanaminium Fluoride Dihydrate; Fluorotetraethylammonium Dihydrate; Tetraethylazanium Fluoride Dihydrate
EINECS	211-556-5

Quality Control

Our Tetraethylammonium Fluoride Dihydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for our global customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent decomposition and maintain efficacy. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	18.0 - 22.0 %
Heavy Metals (as Pb)	≤ 10 ppm
Fluoride Ion Content	≥ 10.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.