Description

3,4-Difluorophenylacetonitrile is a versatile and high-purity fluorinated aromatic nitrile building block essential for advanced organic synthesis. Its molecular structure, featuring both a reactive nitrile group and strategically placed fluorine atoms, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics where the difluorophenyl moiety modulates bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to improve chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl and conjugated systems.
• Nitrile Transformation Chemistry: The cyano group can be readily converted into amides, acids, amines, and heterocycles, enabling diverse molecular diversification.

Basic Information

Product Name	3,4-Difluorophenylacetonitrile
CAS No.	658-99-1
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	(3,4-Difluorophenyl)acetonitrile; 2-(3,4-Difluorophenyl)acetonitrile; 3,4-DFPA; α-Cyano-3,4-difluorotoluene; 3,4-Difluorobenzyl cyanide; 658-99-1; 3,4-Difluorophenylethanenitrile
EINECS	Contact for details

Quality Control

Our 3,4-Difluorophenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.