Description

(4-Fluoro-Phenyl)-Oxo-Acetonitrile is a versatile fluorinated aromatic intermediate with a reactive oxo-acetonitrile functional group. This compound is valued for its role as a key building block in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought by R&D chemists and process development scientists for constructing heterocycles and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic materials.
• Organic Synthesis Building Block: Employed in various name reactions for constructing complex carbon skeletons, particularly in academic and industrial R&D laboratories.
• Ligand and Catalyst Development: Useful for synthesizing novel chelating ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	(4-Fluoro-Phenyl)-Oxo-Acetonitrile
CAS No.	658-13-9
Molecular Formula	C8H4FNO
Molecular Weight	149.12 g/mol
Synonyms	4-Fluorobenzoyl cyanide; 4-Fluorophenylglyoxylonitrile; (4-Fluorobenzoyl)formonitrile; 2-Oxo-2-(4-fluorophenyl)acetonitrile; 4-Fluorobenzoyl cyanide; α-Oxo-4-fluorobenzeneacetonitrile; 4-Fluorophenyl(oxo)acetonitrile; p-Fluorobenzoyl cyanide
EINECS	211-513-9

Quality Control

Our (4-Fluoro-Phenyl)-Oxo-Acetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. This material is moisture-sensitive; ensure containers are kept tightly sealed to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.