Description

(3-Fluoro-Phenyl)-Oxo-Acetonitrile is a versatile fluorinated aromatic building block with a reactive nitrile and ketone functional group. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), advanced materials, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, including kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Ligand and Catalyst Development: Employed in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Organic Synthesis Building Block: Utilized in various name reactions, such as Knoevenagel condensations, to introduce the (3-fluorophenyl)glyoxyloyl moiety.
• Fluorine Chemistry Studies: Acts as a model compound for studying the electronic effects of *meta*-fluorine substitution on adjacent carbonyl and nitrile reactivity.

Basic Information

Product Name	(3-Fluoro-Phenyl)-Oxo-Acetonitrile
CAS No.	658-08-2
Molecular Formula	C8H4FNO
Molecular Weight	149.12 g/mol
Synonyms	2-Oxo-2-(3-fluorophenyl)acetonitrile; 3-Fluorobenzoyl cyanide; (3-Fluorobenzoyl)formonitrile; 3-Fluorophenylglyoxylonitrile; α-Oxo-3-fluorobenzeneacetonitrile; 3-Fluorobenzoylformonitrile; 3-Fluorophenyl(oxo)acetonitrile; 2-(3-Fluorophenyl)-2-oxoacetonitrile
EINECS	211-503-8

Quality Control

Our (3-Fluoro-Phenyl)-Oxo-Acetonitrile is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research and manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.