Description

3,4-Dichloro-5-Nitrobenzotrifluoride is a versatile and high-value fluorinated aromatic intermediate. This compound matters for its unique trifluoromethyl and nitro-substituted dichlorobenzene structure, which is critical for introducing specific electronic and steric properties into target molecules. It is primarily needed by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for synthesizing advanced active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental profile.
• Material Science: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Dye and Pigment Manufacturing: Acts as an intermediate for creating high-performance, light-fast fluorinated dyes and pigments.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures for discovery chemistry.
• Research & Development: A valuable reagent for academic and industrial research exploring new fluorination chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	3,4-Dichloro-5-Nitrobenzotrifluoride
CAS No.	657-02-3
Molecular Formula	C7H2Cl2F3NO2
Molecular Weight	264.00 g/mol
Synonyms	1,2-Dichloro-4-nitro-5-(trifluoromethyl)benzene; 3,4-Dichloro-5-nitro-α,α,α-trifluorotoluene; 5-Nitro-3,4-dichlorobenzotrifluoride; 2,3-Dichloro-6-nitrobenzotrifluoride; 4-Nitro-3,4-dichlorobenzotrifluoride; Benzene, 1,2-dichloro-4-nitro-5-(trifluoromethyl)-; NSC 404082
EINECS	211-500-7

Quality Control

Our 3,4-Dichloro-5-Nitrobenzotrifluoride is manufactured under a cGMP-compliant quality management system, ensuring batch-to-batch consistency for critical R&D and scale-up applications. Every lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed in a dry and well-ventilated place. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	68 - 72 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.