Description

2,4-Difluorophenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the phenyl ring, which can dramatically influence the lipophilicity, metabolic stability, and binding affinity of target molecules. This high-purity intermediate is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting the central nervous system, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides where the difluorophenyl moiety enhances biological activity and environmental profile.
• Liquid Crystal Materials: Used in the research and production of fluorinated liquid crystals for display technologies.
• Organic Electronic Materials: Serves as a starting material for synthesizing fluorinated organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and cyanation for constructing complex biaryl systems.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry in exploring new chemical entities and optimizing synthetic routes.

Basic Information

Product Name	2,4-Difluorophenylacetonitrile
CAS No.	656-35-9
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	(2,4-Difluorophenyl)acetonitrile; 2,4-DFPA; α-Cyano-2,4-difluorotoluene; 2,4-Difluorobenzyl cyanide; (2,4-Difluorobenzyl)cyanide; 2,4-Difluoro-α-tolunitrile; 656-35-9; EINECS 211-500-4
EINECS	211-500-4

Quality Control

Our 2,4-Difluorophenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.