Description

2,6-Difluorophenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring two fluorine atoms in the ortho positions relative to the reactive acetonitrile side chain, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including herbicides, fungicides, and pharmaceutical candidates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a difluorophenyl moiety for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a fundamental building block for developing new-generation herbicides, fungicides, and plant growth regulators.
• Liquid Crystal & OLED Materials: Used in the research and production of fluorinated organic electronic materials for displays and lighting.
• Advanced Polymer Chemistry: Acts as a monomer or modifier in the synthesis of specialty polymers with unique chemical resistance and thermal properties.
• Organic Synthesis & Catalysis Research: A valuable reagent for palladium-catalyzed cross-coupling reactions (e.g., cyanoalkylation) and other C-C bond-forming processes in academic and industrial R&D.
• Fluorine Chemistry Studies: Essential compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in molecular design.

Basic Information

Item	Detail
Product Name	2,6-Difluorophenylacetonitrile
CAS No.	654-01-3
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	2,6-Difluorobenzeneacetonitrile; (2,6-Difluorophenyl)acetonitrile; α-Cyano-2,6-difluorotoluene; 2,6-Difluorobenzyl cyanide; 654-01-3; 2,6-Difluoro-α-tolunitrile
EINECS	211-492-5

Quality Control

Our 2,6-Difluorophenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The compound is moisture-sensitive; keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.