Description

Allotetrahydrocortisol CAS NO 651-43-4 is a significant steroid metabolite and a key intermediate in the synthesis of various pharmaceutical compounds. Its importance lies in its role as a precursor for the development of corticosteroids and other therapeutic agents, offering a critical building block for advanced pharmaceutical manufacturing. This product is essential for research institutions, pharmaceutical R&D laboratories, and fine chemical producers focused on steroid chemistry and drug development.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly corticosteroids and related steroid-based therapeutics.
• Biochemical Research: Used as a reference standard and analytical reagent in metabolic studies, hormone research, and enzymatic pathway investigations.
• Steroid Chemistry Development: Serves as a key starting material or intermediate for medicinal chemists developing novel steroid derivatives with targeted biological activity.
• Metabolite Analysis: Employed in clinical and diagnostic research as a calibrant or standard for quantifying cortisol and related steroid metabolites in biological samples via LC-MS or HPLC.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing specialized, high-value steroid compounds.

Basic Information

Product Name	Allotetrahydrocortisol
CAS No.	651-43-4
Molecular Formula	C21H34O5
Molecular Weight	366.49 g/mol
Synonyms	3α,11β,17α,21-Tetrahydroxy-5β-pregnan-20-one; 5β-Tetrahydrocortisol; allo-Tetrahydrocortisol; (3α,5β,11β)-3,11,17,21-Tetrahydroxypregnan-20-one; Urocortisol; THF; 5β-THF; 3α,11β,17α,21-Tetrahydroxy-5β-pregnan-20-one
EINECS	Contact for details

Quality Control

Our Allotetrahydrocortisol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.