Description

Desonide 1,2-Saturated CAS NO 638-93-7 is a specific, saturated derivative of the topical corticosteroid desonide, characterized by the hydrogenation of the 1,2-double bond in its steroid nucleus. This modification can influence the compound's stability, solubility, and metabolic profile, making it a valuable intermediate for advanced pharmaceutical research and development. It is primarily sought by manufacturers and R&D laboratories in the pharmaceutical and fine chemical sectors for the synthesis of novel steroid-based therapeutics and for analytical reference purposes.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the multi-step synthesis of novel topical corticosteroid analogs and prodrugs.
• Research & Development: Used in pharmacological and metabolic studies to understand structure-activity relationships (SAR) of steroid derivatives.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical testing laboratories.
• Process Chemistry: Employed in route scouting and optimization for the industrial-scale production of related steroid active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Desonide 1,2-Saturated
CAS No.	638-93-7
Molecular Formula	C24H32O6
Molecular Weight	416.51 g/mol
Synonyms	11β,21-Dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione; Dihydrodesonide; 1,2-Dihydrodesonide; 1,2,4,5-Tetrahydrodesonide; 1,2-Saturated Desonide; 9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone (saturated); Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α)-
EINECS	Contact for details

Quality Control

Our Desonide 1,2-Saturated is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.