Description

Prednisolone 21-(3-Sodium-Sulphobenzoate) CAS NO 630-67-1 is a water-soluble prodrug derivative of the potent glucocorticoid prednisolone, designed to enhance bioavailability and facilitate parenteral administration. This modification is critical for achieving rapid therapeutic effects in clinical settings where immediate anti-inflammatory and immunosuppressive action is required. It is an essential active pharmaceutical ingredient (API) and key intermediate for manufacturers developing injectable corticosteroid formulations targeting severe allergic reactions, autoimmune disorders, and certain oncological conditions.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable anti-inflammatory and immunosuppressive medications.
• Veterinary Medicine: Formulation of treatments for inflammation and immune-mediated diseases in animals.
• Research & Development: Critical biochemical tool for studying glucocorticoid receptor activity, inflammation pathways, and prodrug metabolism.
• High-Purity Intermediate: Serves as a key synthetic precursor for further chemical modification in advanced steroid synthesis.
• Hospital Compounding: Used in specialized pharmacy settings for preparing tailored injectable solutions.

Basic Information

Product Name	Prednisolone 21-(3-Sodium-Sulphobenzoate)
CAS No.	630-67-1
Molecular Formula	C28H31NaO8S
Molecular Weight	550.60 g/mol
Synonyms	Prednisolone Sodium Succinate (common misnomer for related compound, often used in searches); Prednisolone 21-Hemisuccinate Sodium Salt (related compound); Prednisolone 21-Sulfobenzoate Sodium; Sodium Prednisolone Succinate; Soluble Prednisolone; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(3-carboxy-1-oxopropoxy)-, monosodium salt (complex IUPAC); PSOL; Water-soluble Prednisolone Ester.
EINECS	211-147-5

Quality Control

Our Prednisolone 21-(3-Sodium-Sulphobenzoate) is manufactured under strict quality management systems. We provide material that typically meets or exceeds pharmaceutical-grade specifications, with rigorous testing for identity, purity, and potency. A comprehensive Certificate of Analysis (COA) is supplied with each batch, detailing results for assay, related substances, residual solvents, and microbiological limits. Our quality commitment ensures compliance with ICH Q7 guidelines and supports our customers' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and may be hygroscopic; therefore, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
pH (5% solution)	6.5 - 8.5
Bacterial Endotoxins	< 0.17 EU/mg (for injectable grade)
Microbiological Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.