Description

6-Dehydrocortisol is a key synthetic corticosteroid intermediate of significant importance in pharmaceutical research and development. This compound is primarily valued for its role as a versatile precursor in the synthesis of more complex steroid-based active pharmaceutical ingredients (APIs). It is essential for researchers and manufacturers in the pharmaceutical industry, particularly those focused on developing anti-inflammatory, immunosuppressive, and hormonal therapies.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of potent corticosteroid drugs such as cortisone, hydrocortisone, and their derivatives.
• Steroid Research: Used as a reference standard and starting material in academic and industrial research to study steroid metabolism, structure-activity relationships (SAR), and biological pathways.
• API Development: Serves as a precursor in the development and scale-up of new steroid-based Active Pharmaceutical Ingredients (APIs) for clinical trials and commercial production.
• Biochemical Studies: Employed in enzymatic and metabolic studies to investigate the biosynthesis and degradation pathways of endogenous corticosteroids.

Basic Information

Product Name	6-Dehydrocortisol
CAS No.	600-99-7
Molecular Formula	C₂₁H₂₈O₅
Molecular Weight	360.45 g/mol
Synonyms	11β,17α,21-Trihydroxypregna-4,6-diene-3,20-dione; 6-Dehydrohydrocortisone; 6,7-Dehydrocortisol; 17α,21-Dihydroxy-4,6-pregnadiene-3,11,20-trione; NSC 9705; 6-Dehydro-11β,17α,21-trihydroxypregn-4-ene-3,20-dione
EINECS	Contact for details

Quality Control

Our 6-Dehydrocortisol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to minimize exposure to atmospheric moisture and light to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.