Description

Hydroxyzine is a first-generation antihistamine and anxiolytic agent belonging to the piperazine derivative class. This compound is a critical active pharmaceutical ingredient (API) valued for its efficacy in managing anxiety, pruritus, and as a pre-operative sedative. It is essential for pharmaceutical manufacturers developing prescription medications for the treatment of allergic conditions and anxiety disorders. Hydroxyzine CAS NO 68-88-2 is supplied as a high-purity intermediate to meet the stringent requirements of global drug production.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription antihistamine and anxiolytic medications.
• Anxiety Disorder Treatment: Formulated into tablets and syrups for the management of generalized anxiety and tension.
• Antipruritic Agent: Used in medications to relieve itching caused by allergic conditions such as chronic urticaria and atopic dermatitis.
• Pre-operative Sedation: Employed as a sedative to alleviate anxiety and provide sedation before surgery.
• Antiemetic Formulations: Incorporated into therapies to help control nausea and vomiting.
• Research & Development: Serves as a reference standard and key intermediate in pharmacological research and new drug development.

Basic Information

Product Name	Hydroxyzine
CAS No.	68-88-2
Molecular Formula	C21H27ClN2O2
Molecular Weight	374.91 g/mol
Synonyms	Hydroxyzine Hydrochloride; Hydroxyzine Dihydrochloride; 1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine; Atarax; Vistaril; Masmoran; Paxistil; Tran-Q; Ildamen; Placidyl
EINECS	200-694-7

Quality Control

Our Hydroxyzine is manufactured under strict quality management systems to ensure it meets the highest standards for pharmaceutical use. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via advanced techniques like HPLC and GC. We provide full traceability and support compliance with major pharmacopoeial standards (USP/EP). Certificates of Analysis (COA) documenting all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Microbial Limits	Meets USP/EP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.