Description

Promethazine is a phenothiazine derivative with significant antihistaminic and sedative properties, widely recognized for its therapeutic efficacy. This compound is a critical active pharmaceutical ingredient (API) essential for the formulation of various medicinal products. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development of treatments for allergic conditions, motion sickness, and as a pre-operative sedative.

Application

• Active Pharmaceutical Ingredient (API) in antihistamine medications for allergy relief.
• Key component in antiemetic formulations to prevent nausea and vomiting, particularly associated with motion sickness.
• Used as a sedative in pre-operative and post-operative medical care.
• Intermediate in advanced pharmaceutical synthesis and research for new therapeutic agents.
• Utilized in veterinary medicine for its calming and anti-allergic effects.
• Reference standard in analytical laboratories for quality control and method development.

Basic Information

Product Name	Promethazine
CAS No.	60-87-7
Molecular Formula	C17H20N2S
Molecular Weight	284.42 g/mol
Synonyms	Promethazine Hydrochloride (common salt form); N-(2-Dimethylamino-2-methylethyl)phenothiazine; 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-; Phenergan (trade name); Atosil; Lergigan; Prothazin; Diprazin; Pipolphen; Promazinamide; Dimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)-amine
EINECS	200-500-6

Quality Control

Our Promethazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and can be tailored to meet specific pharmacopoeial requirements such as USP or EP.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.