Description

5-(Trifluoromethyl)-1,1-Biphenyl-4-Carbonitrile CAS NO 582293-43-4 is a high-purity, advanced pharmaceutical intermediate characterized by its biphenyl core and trifluoromethyl and nitrile functional groups. This compound is of significant commercial value for its role in the synthesis of complex molecules, particularly in medicinal chemistry where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Liquid Crystal & OLED Materials: Serves as a precursor in the production of advanced electronic materials for displays and organic light-emitting diodes due to its rigid biphenyl structure.
• Cross-Coupling Reactions: An essential substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct more complex biaryl systems.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.
• Fluorine Chemistry Studies: Used as a model compound in studying the effects of fluorine substitution on molecular properties and reactivity.

Basic Information

Product Name	5-(Trifluoromethyl)-1,1-Biphenyl-4-Carbonitrile
CAS No.	582293-43-4
Molecular Formula	C14H8F3N
Molecular Weight	247.22 g/mol
Synonyms	4'-Cyano-4-(trifluoromethyl)biphenyl; [1,1'-Biphenyl]-4-carbonitrile, 5-(trifluoromethyl)-; 4-(Trifluoromethyl)biphenyl-4'-carbonitrile; 5-(Trifluoromethyl)-[1,1'-biphenyl]-4-carbonitrile; 4-Cyano-4'-(trifluoromethyl)biphenyl; 4'-Trifluoromethyl-4-cyanobiphenyl; 5-(Trifluoromethyl)biphenyl-4-carbonitrile
EINECS	Contact for details

Quality Control

Our production of 5-(Trifluoromethyl)-1,1-Biphenyl-4-Carbonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical specifications. Our quality system is designed to support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.