Description

3-(Hydroxymethyl)-5-(Trifluoromethyl)Benzonitrile is a versatile aromatic nitrile derivative featuring both hydroxymethyl and trifluoromethyl functional groups, making it a valuable bifunctional building block in advanced organic synthesis. This compound is particularly significant for its role in the development of pharmaceuticals and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a critical building block for developing new herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Liquid Crystal & OLED Materials: Used in the research and production of advanced electronic display materials and organic light-emitting diodes (OLEDs) due to its aromatic core and functional handles.
• Polymer & Resin Modifier: Acts as a monomer or cross-linking agent to introduce cyanide and fluorinated groups into polymers, enhancing their chemical resistance and thermal properties.
• Chemical Research & Development: A versatile reagent for medicinal chemistry and process chemistry, enabling structure-activity relationship (SAR) studies and scale-up synthesis.
• Fluorinated Dye & Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments where fluorine substitution alters light absorption and stability.

Basic Information

Product Name	3-(Hydroxymethyl)-5-(Trifluoromethyl)Benzonitrile
CAS No.	569370-38-3
Molecular Formula	C9H6F3NO
Molecular Weight	201.15 g/mol
Synonyms	5-(Trifluoromethyl)-3-cyanobenzyl alcohol; [3-(Hydroxymethyl)-5-(trifluoromethyl)phenyl] cyanide; 3-Cyanobenzyl alcohol, 5-(trifluoromethyl)-; 3-(Hydroxymethyl)-α,α,α-trifluoro-m-tolunitrile; m-Tolunitrile, 3-(hydroxymethyl)-α,α,α-trifluoro-; 5-(Trifluoromethyl)isophthalonitrile, 3-hydroxy- (tautomer); Benzonitrile, 3-(hydroxymethyl)-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3-(Hydroxymethyl)-5-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.