Description

2,5-Bis(Trifluoromethyl)Acetophenone is a high-value fluorinated aromatic ketone building block, distinguished by its two strategically positioned trifluoromethyl groups. This compound is critical for introducing lipophilicity and metabolic stability into advanced molecular architectures, making it a sought-after intermediate in sophisticated chemical synthesis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with unique surface properties, chemical resistance, and thermal stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic additions, and reductions to construct complex, fluorinated molecules for various R&D applications.
• Material Science Research: Used in academic and industrial labs to develop new fluorinated coatings, sensors, and advanced functional materials.

Basic Information

Product Name	2,5-Bis(Trifluoromethyl)Acetophenone
CAS No.	545410-47-7
Molecular Formula	C10H5F6O
Molecular Weight	270.14 g/mol
Synonyms	1-[2,5-Bis(trifluoromethyl)phenyl]ethanone; 2',5'-Bis(trifluoromethyl)acetophenone; α,α,α,α',α',α'-Hexafluoro-2,5-dimethylacetophenone; 2,5-Di(trifluoromethyl)acetophenone; Acetophenone, 2,5-bis(trifluoromethyl)-; Ethanone, 1-[2,5-bis(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Every batch of 2,5-Bis(Trifluoromethyl)Acetophenone is manufactured and tested under a strict quality management system. We guarantee high-purity material suitable for demanding synthetic applications. Comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, is performed to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom specifications can be supported for cGMP or other regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.