Description

6α,9α-Difluoro-11β,17,21-Trihydroxy-16β-Methylpregna-1,4-Diene-3,20-Dione, 21-Propionate is a high-purity synthetic corticosteroid derivative, specifically a fluorinated and esterified pregnadiene. This compound is a critical pharmaceutical intermediate valued for its potent anti-inflammatory and immunosuppressive activity profile. It is primarily required by pharmaceutical R&D and manufacturing sectors for the development and production of advanced topical and systemic corticosteroid medications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent topical corticosteroids for dermatological conditions like eczema, psoriasis, and dermatitis.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor or the core structure in the research and production of novel glucocorticoid receptor agonists.
• Anti-inflammatory Drug Research: Used in preclinical and clinical research to study mechanisms of action and efficacy of new steroid-based therapies.
• Veterinary Medicine: Potential application in developing anti-inflammatory treatments for animals.
• Reference Standard: Serves as an analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Tool compound for studying steroid hormone receptor interactions and metabolic pathways.

Basic Information

Product Name	6α,9α-Difluoro-11β,17,21-Trihydroxy-16β-Methylpregna-1,4-Diene-3,20-Dione, 21-Propionate
CAS No.	541502-98-1
Molecular Formula	C25H31FO6
Molecular Weight	446.51 g/mol
Synonyms	Difluoromethylprednisolone Propionate; 6α,9α-Difluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-propionate; 16β-Methyl-6α,9α-difluoroprednisolone 21-propionate; 6α,9α-Difluoro-16β-methylprednisolone 21-propionate; Difluoromethylprednisolone 21-propanoate; (6α,9α-Difluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione) 21-propionate
EINECS	Contact for details

Quality Control

Our 6α,9α-Difluoro-11β,17,21-Trihydroxy-16β-Methylpregna-1,4-Diene-3,20-Dione, 21-Propionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing specifications and test results are provided with every shipment to guarantee supply chain transparency and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity, the material should be stored under an inert atmosphere to prevent oxidation. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.