Description

2-(4-Bromo-2,6-Difluorophenyl)Acetonitrile is a versatile and high-purity halogenated aromatic nitrile building block essential for advanced organic synthesis. Its molecular structure, featuring bromine and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the bioactivity of difluorophenyl motifs.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination due to the reactive bromine atom.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic pathways and creating compound libraries for screening.
• Fluorine Chemistry Studies: Used as a model compound in studying the effects of fluorine substitution on reaction kinetics and molecular properties.

Basic Information

Product Name	2-(4-Bromo-2,6-Difluorophenyl)Acetonitrile
CAS No.	537033-52-6
Molecular Formula	C8H4BrF2N
Molecular Weight	232.03 g/mol
Synonyms	(4-Bromo-2,6-difluorophenyl)acetonitrile; 2-(4-Bromo-2,6-difluorophenyl)ethanenitrile; 4-Bromo-2,6-difluorobenzyl cyanide; α-Cyano-4-bromo-2,6-difluorotoluene; 4-Bromo-2,6-difluorobenzeneacetonitrile; 2,6-Difluoro-4-bromophenylacetonitrile; (4-Bromo-2,6-difluorobenzyl) cyanide
EINECS	Contact for details

Quality Control

Our 2-(4-Bromo-2,6-Difluorophenyl)Acetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.