Description

tert-Butyl 2-Fluoro-5-Nitrophenylcarbamate is a high-purity, protected aniline derivative used as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecules, particularly in pharmaceutical research and development. It is essential for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the fluorine and nitro functional groups impart specific biological activity.
• Peptide Mimetics & PROTACs: Serves as a protected aniline fragment for constructing non-peptidic scaffolds and proteolysis-targeting chimeras (PROTACs).
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials requiring specific aromatic amine functionalities.
• Chemical Biology Probes: Utilized as a building block for creating fluorescent tags and molecular probes for biological target identification.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	tert-Butyl 2-Fluoro-5-Nitrophenylcarbamate
CAS No.	535170-15-1
Molecular Formula	C11H13FN2O4
Molecular Weight	256.23 g/mol
Synonyms	tert-Butyl N-(2-Fluoro-5-nitrophenyl)carbamate; Carbamic acid, N-(2-fluoro-5-nitrophenyl)-, 1,1-dimethylethyl ester; 2-Fluoro-5-nitroaniline, N-Boc protected; Boc-2-Fluoro-5-nitroaniline; N-Boc-2-fluoro-5-nitroaniline; N-(tert-Butoxycarbonyl)-2-fluoro-5-nitroaniline; 535170-15-1; tert-Butyl (2-fluoro-5-nitrophenyl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Fluoro-5-Nitrophenylcarbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.