Description

2-Propanone, 1,1,1-Trifluoro-3-(1H-1,2,4-Triazol-1-Yl)- is a high-value fluorinated triazole derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique molecular structure, featuring both a trifluoroacetone moiety and a 1,2,4-triazole ring, makes it indispensable for constructing complex molecules with enhanced biological activity and physicochemical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antifungal, antiviral, and anticancer drug candidates, leveraging the bioactive 1,2,4-triazole scaffold.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the fluorine atoms contribute to improved metabolic stability and membrane permeability.
• Material Science Research: Serves as a precursor for developing specialty polymers, ligands for catalysis, and fluorinated organic frameworks with unique electronic properties.
• Chemical Biology & Proteomics: Employed as a versatile handle or "tag" in the design of chemical probes and activity-based protein profiling (ABPP) agents.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Propanone, 1,1,1-Trifluoro-3-(1H-1,2,4-Triazol-1-Yl)-
CAS No.	522634-27-1
Molecular Formula	C5H4F3N3O
Molecular Weight	179.10 g/mol
Synonyms	1,1,1-Trifluoro-3-(1H-1,2,4-triazol-1-yl)propan-2-one; 3-(1H-1,2,4-Triazol-1-yl)-1,1,1-trifluoroacetone; 1,1,1-Trifluoro-3-(1,2,4-triazol-1-yl)acetone; 1-(1,1,1-Trifluoro-3-oxopropyl)-1H-1,2,4-triazole; 1,1,1-Trifluoro-3-(1H-1,2,4-triazol-1-yl)-2-propanone; Fluorinated Triazolyl Acetone; TTA Intermediate
EINECS	Contact for details

Quality Control

Our 2-Propanone, 1,1,1-Trifluoro-3-(1H-1,2,4-Triazol-1-Yl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.