Description

Benzeneacetonitrile, 2-Fluoro-4-Methyl- (9Ci) is a specialized fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce fluorine and cyano functional groups into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, including kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the development of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Employed as a monomer or modifier to introduce polar nitrile groups and fluorine into high-performance polymers and resins.
• Chemical Research & Development: A versatile building block for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic substitution reactions in academic and industrial labs.
• Fluorine-18 Radiochemistry: Potential precursor for the synthesis of PET (Positron Emission Tomography) imaging agents, though typically requiring specialized handling facilities.

Basic Information

Product Name	Benzeneacetonitrile, 2-Fluoro-4-Methyl- (9Ci)
CAS No.	518070-26-3
Molecular Formula	C9H8FN
Molecular Weight	149.17 g/mol
Synonyms	2-Fluoro-4-Methylbenzyl Cyanide; (2-Fluoro-4-methylphenyl)acetonitrile; 2-Fluoro-4-methylbenzeneacetonitrile; 2-Fluoro-p-tolylacetonitrile; 4-Methyl-2-fluorobenzyl cyanide; α-Cyano-2-fluoro-4-methyltoluene; 2-Fluoro-4-methylphenylacetonitrile; 518070-26-3
EINECS	Contact for details

Quality Control

Our Benzeneacetonitrile, 2-Fluoro-4-Methyl- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.