Description

Benzonitrile, 2,3-Difluoro-4-Methyl- (9Ci) is a high-purity fluorinated aromatic nitrile building block, distinguished by its specific substitution pattern. This compound is critical for advanced organic synthesis, offering a versatile handle for introducing difluoromethyl-substituted aromatic motifs into complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine atoms into polymer backbones, improving chemical resistance and thermal stability.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings to build complex biaryl systems.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and creating compound libraries for high-throughput screening.

Basic Information

Product Name	Benzonitrile, 2,3-Difluoro-4-Methyl- (9Ci)
CAS No.	508203-48-3
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	2,3-Difluoro-4-methylbenzonitrile; 4-Methyl-2,3-difluorobenzonitrile; 2,3-Difluoro-p-tolunitrile; 2,3-Difluoro-4-methylbenzenecarbonitrile; Benzonitrile, 2,3-difluoro-4-methyl-; 508203-48-3; 2,3-Difluoro-4-methyl-benzonitrile
EINECS	Contact for details

Quality Control

Our Benzonitrile, 2,3-Difluoro-4-Methyl- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in cGMP environments and research requiring the highest material integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider maintaining under an inert atmosphere to preserve purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.