Description

2-Propen-1-One, 1-(4-Acetylphenyl)-2-Fluoro- (9Ci) is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceutical candidates and functional materials, where the strategic incorporation of fluorine atoms can dramatically alter biological activity and material properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, where the fluorine moiety enhances metabolic stability and bioavailability.
• Material Science: Acts as a monomer or cross-linking agent in the production of specialty polymers with tailored optical or electronic properties.
• Liquid Crystal & OLED Development: Employed in the synthesis of fluorinated organic semiconductors and liquid crystal molecules for display technologies.
• Chemical Biology Probes: Utilized to create fluorinated probes and tags for studying biological mechanisms and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-Propen-1-One, 1-(4-Acetylphenyl)-2-Fluoro- (9Ci)
CAS No.	506437-39-4
Molecular Formula	C11H9FO2
Molecular Weight	192.19 g/mol
Synonyms	1-(4-Acetylphenyl)-2-fluoro-2-propen-1-one; 2-Fluoro-1-(4-acetylphenyl)prop-2-en-1-one; 4-Acetyl-α-fluorocinnamaldehyde; 4-Acetyl-2-fluorocinnamaldehyde; (E)-1-(4-Acetylphenyl)-2-fluoroprop-2-en-1-one; 4-Acetyl-α-fluorocinnaldehyde; Fluorinated Chalcone Derivative; 506437-39-4
EINECS	Contact for details

Quality Control

Every batch of 2-Propen-1-One, 1-(4-Acetylphenyl)-2-Fluoro- (9Ci) is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), impurity profile, and physical characteristics. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.