Description

3-Bromo-4-Fluorobenzeneacetonitrile is a versatile and high-value aromatic nitrile building block, distinguished by its bromo and fluoro substituents. This compound is critical for facilitating advanced molecular construction in pharmaceutical and agrochemical research, offering precise sites for further functionalization. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors for synthesizing complex active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides, leveraging the bioactivity of the fluorinated aromatic system.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for advanced electronic materials, including liquid crystal displays and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings.
• Cyanohydrin & Acid Derivative Synthesis: The nitrile group can be hydrolyzed to corresponding acids or reduced to amines for further diversification.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	3-Bromo-4-Fluorobenzeneacetonitrile
CAS No.	501420-63-9
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	(3-Bromo-4-fluorophenyl)acetonitrile; 2-(3-Bromo-4-fluorophenyl)acetonitrile; 3-Bromo-4-fluorobenzyl cyanide; 4-Fluoro-3-bromobenzeneacetonitrile; 3-Bromo-4-fluorophenylacetonitrile; α-Cyano-3-bromo-4-fluorotoluene; 3-Bromo-4-fluoro-α-tolunitrile
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Fluorobenzeneacetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.