Description

N,n-Diethyl-Alpha,α-Difluoro-3-Methylbenzylamine is a specialized fluorinated amine building block of significant interest in advanced organic synthesis. Its value lies in the strategic incorporation of fluorine and amine functionalities, which are critical for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis, leveraging the amine functionality for metal coordination or activation.
• Material Science Research: Employed in the synthesis of fluorinated polymers or specialty chemicals where fluorine atoms impart unique properties like chemical resistance or low surface energy.
• Fluorine Chemistry Building Block: Essential for introducing the valuable -CF2- moiety into complex organic architectures in academic and industrial research settings.

Basic Information

Product Name	N,n-Diethyl-Alpha,α-Difluoro-3-Methylbenzylamine
CAS No.	500131-50-0
Molecular Formula	C12H17F2N
Molecular Weight	213.27 g/mol
Synonyms	α,α-Difluoro-3-methyl-N,N-diethylbenzylamine; 1-(Diethylamino)-2,2-difluoro-1-(3-methylphenyl)methane; N,N-Diethyl-α,α-difluoro-m-tolylmethylamine; Benzylamine, α,α-difluoro-N,N-diethyl-3-methyl-; 3-Methyl-α,α-difluoro-N,N-diethylbenzenemethanamine; N,N-Diethyl-1-(3-methylphenyl)-2,2-difluoroethanamine; Difluoro(m-tolyl)methyl(diethyl)amine
EINECS	Contact for details

Quality Control

Our N,n-Diethyl-Alpha,α-Difluoro-3-Methylbenzylamine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong acids and strong oxidizing agents. Due to its fluoride/strong alkali nature, ensure containers are kept tightly sealed and stored separately from reactive compounds.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.