Description

(5S,8S,9R,10S,13S,14S,17S)-9-Fluoro-17-Hydroxy-10,13,17-Trimethyl-2,4,5,6,7,8,12,14,15,16-Decahydro-1H-Cyclopenta[A]Phenanthrene-3,11-Dione is a high-purity, fluorinated steroid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate for creating novel therapeutic agents, particularly in the fields of endocrinology and oncology. It is primarily utilized by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) focused on developing next-generation steroid-based drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel fluorinated corticosteroids and other potent steroid-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry programs to study structure-activity relationships (SAR) and develop new drug candidates targeting hormone receptors.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Process Chemistry: Employed in scaling up synthetic routes for the commercial production of complex steroid molecules.
• Biochemical Research: Used as a tool compound in biochemical assays to investigate steroid metabolism and enzyme inhibition.

Basic Information

Product Name	(5S,8S,9R,10S,13S,14S,17S)-9-Fluoro-17-Hydroxy-10,13,17-Trimethyl-2,4,5,6,7,8,12,14,15,16-Decahydro-1H-Cyclopenta[A]Phenanthrene-3,11-Dione
CAS No.	59981-94-1
Molecular Formula	C20H25FO3
Molecular Weight	332.41 g/mol
Synonyms	9-Fluoro-11β,17-dihydroxy-10,13,17-trimethyl-1,2,4,5,6,7,8,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-3,11-dione; 9-Fluoro-17-hydroxy-10,13,17-trimethyldodecahydrocyclopenta[a]phenanthrene-3,11-dione; Fluorinated Steroid Dione Intermediate; 9-Fluoro-δ1-Corticosterone derivative
EINECS	Contact for details

Quality Control

Our (5S,8S,9R,10S,13S,14S,17S)-9-Fluoro-17-Hydroxy-10,13,17-Trimethyl-2,4,5,6,7,8,12,14,15,16-Decahydro-1H-Cyclopenta[A]Phenanthrene-3,11-Dione is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and MS analysis. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.