Description

2-Acetyl-1,2,3,4-Tetrahydro-6-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]-7-Methoxyisoquinoline is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and neurological pathways. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules, particularly β-adrenergic blocking agents (β-blockers).
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the research and commercial production of specific cardiovascular and neurological APIs.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies and the discovery of new chemical entities.
• Contract Manufacturing: Supplied to CDMOs for cGMP-compliant production of clinical trial materials and commercial drug substances.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	2-Acetyl-1,2,3,4-Tetrahydro-6-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]-7-Methoxyisoquinoline
CAS No.	59839-39-3
Molecular Formula	C20H30N2O4
Molecular Weight	362.47 g/mol
Synonyms	6-[2-Hydroxy-3-(isopropylamino)propoxy]-2-acetyl-1,2,3,4-tetrahydro-7-methoxyisoquinoline; 2-Acetyl-6-[2-hydroxy-3-(isopropylamino)propoxy]-1,2,3,4-tetrahydro-7-methoxyisoquinoline; 6-[2-Hydroxy-3-[(1-Methylethyl)amino]propoxy]-2-acetyl-1,2,3,4-tetrahydro-7-methoxyisoquinoline; CAS 59839-39-3; ATHP; A key intermediate for certain β-blockers.
EINECS	Contact for details

Quality Control

Our 2-Acetyl-1,2,3,4-Tetrahydro-6-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]-7-Methoxyisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting standards for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.