Description

(+/-)-Bufuralol Hydrochloride CAS NO 59652-29-8 is a non-selective β-adrenergic receptor antagonist (β-blocker) used extensively in pharmacological research and development. Its core value lies in its utility as a key reference standard and active pharmaceutical ingredient (API) intermediate for studying cardiovascular and neurological pathways. This compound is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in drug discovery, metabolic studies, and analytical method validation.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments (HPLC, LC-MS) and the validation of assay methods in quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical building block in the synthesis of β-blocker medications and related pharmacologically active compounds.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate β-adrenergic receptor binding, inhibition, and associated cardiovascular effects.
• Metabolite Studies: Utilized as a parent compound for researching metabolic pathways, including cytochrome P450-mediated reactions like debrisoquine hydroxylation polymorphism.
• Pharmacology & Toxicology Screening: Applied in preclinical research to assess the efficacy, potency, and safety profile of β-adrenergic blocking agents.

Basic Information

Product Name	(+/-)-Bufuralol Hydrochloride
CAS No.	59652-29-8
Molecular Formula	C16H25NO2 • HCl
Molecular Weight	299.84 g/mol (as hydrochloride salt)
Synonyms	Bufuralol HCl; 1-(2,3-Dihydro-7-ethyl-1-benzofuran-2-yl)-2-(tert-butylamino)ethanol Hydrochloride; Bufuralol Hydrochloride (racemic); DL-Bufuralol Hydrochloride; (±)-Bufuralol Hydrochloride; Bufetolol (common name variant); Ro 03-4787 (developmental code)
EINECS	Contact for details

Quality Control

Our (+/-)-Bufuralol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles by HPLC is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.