Description

2-Chloro-6Beta,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate) is a high-purity synthetic corticosteroid derivative, serving as a critical advanced intermediate in pharmaceutical manufacturing. Its value lies in providing a structurally complex, fluorinated steroid backbone essential for the synthesis of potent anti-inflammatory and immunosuppressive APIs. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development and production of next-generation topical and systemic corticosteroid therapies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel fluorinated corticosteroid active pharmaceutical ingredients (APIs).
• Anti-inflammatory Drug Research: Used in R&D for developing potent topical creams, ointments, and inhalants targeting dermatological and respiratory conditions.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale manufacturing of steroid-based pharmaceuticals.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor interactions and steroid hormone activity.

Basic Information

Item	Detail
Product Name	2-Chloro-6Beta,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate)
CAS No.	59047-08-4
Molecular Formula	C₂₅H₂₈ClF₂O₇
Molecular Weight	513.94 g/mol
Synonyms	Clobetasol 17,21-Diacetate; 2-Chloro-6β,9-difluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-diacetate; 6β,9-Difluoro-11β,17,21-trihydroxy-2-chloropregna-1,4-diene-3,20-dione 17,21-diacetate; Clobetasol Diacetate; Clobetasol 17-Acetate 21-Acetate; 17α,21-Diacetoxy-2-chloro-6α,9-difluoro-11β-hydroxy-1,4-pregnadiene-3,20-dione; (6β,11β)-2-Chloro-6,9-difluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione diacetate
EINECS	Contact for details

Quality Control

Our 2-Chloro-6Beta,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) documenting HPLC purity, related substances, and residual solvents are available upon request. We adhere to cGMP principles where applicable to support our global clientele in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.