Description

Idarubicin is a potent anthracycline antineoplastic agent, a key intermediate in the synthesis of the active pharmaceutical ingredient Idarubicin Hydrochloride. This compound is critical for the development of chemotherapeutic treatments targeting specific cancers. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in oncology drug development and production.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a crucial intermediate in the commercial manufacturing of Idarubicin Hydrochloride injection.
• Oncology Research & Development: Serves as a reference standard and building block in preclinical studies for novel cancer therapies.
• Pharmaceutical Formulation: Used in the development and scale-up of finished dosage forms for acute leukemia treatments.
• Biochemical Research: Employed in studies investigating the mechanism of action of topoisomerase II inhibitors and DNA intercalation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of generic and branded oncology drugs.

Basic Information

Product Name	Idarubicin
CAS No.	58957-92-9
Molecular Formula	C26H27NO9
Molecular Weight	497.49 g/mol
Synonyms	4-Demethoxydaunorubicin; 4-DMDR; Idarubicinum; Idarubicina; (7S,9S)-9-Acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; NSC 256439; Zavedos Intermediate
EINECS	Contact for details

Quality Control

Our Idarubicin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed chromatographic data are provided to support regulatory submissions and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Orange-red to red powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.