Description

(7R-Cis)-9-Acetyl-7-((3-Amino-2,3,6-Trideoxy-α-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,9,11-Trihydroxy-5,12-Naphthacenedione is a structurally complex anthracycline derivative, a class of compounds renowned for their potent biological activity. This compound is of significant interest for its role as a key synthetic intermediate or reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions and manufacturers engaged in the synthesis of novel therapeutic agents, particularly in the fields of oncology and anti-infectives. The precise stereochemistry and functional groups make it a critical building block for producing targeted, high-value active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of sophisticated anthracycline-based chemotherapeutic agents.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC/QA) of related drug substances and products.
• Biochemical Research: Employed in life science research to study structure-activity relationships (SAR), mechanism of action, and DNA-intercalation properties of anthracyclines.
• Process Development: Utilized by process chemists for scaling up and optimizing synthetic routes for new chemical entities (NCEs) in pilot plants.
• Academic Research: A valuable compound for universities and research institutes conducting studies in medicinal chemistry and organic synthesis.

Basic Information

Product Name	(7R-Cis)-9-Acetyl-7-((3-Amino-2,3,6-Trideoxy-α-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,9,11-Trihydroxy-5,12-Naphthacenedione
CAS No.	58957-91-8
Molecular Formula	C27H29NO11
Molecular Weight	543.52 g/mol
Synonyms	9-Acetyl-7-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione; (7R,9S)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione; 7R-Cis Isomer of an Anthracycline Glycoside; Daunorubicin Related Compound; 4-Demethoxy-13-dihydrodaunorubicin derivative
EINECS	Contact for details

Quality Control

Our (7R-Cis)-9-Acetyl-7-((3-Amino-2,3,6-Trideoxy-α-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,9,11-Trihydroxy-5,12-Naphthacenedione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, spectroscopic identification (IR, NMR), and tests for residual solvents and moisture to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	97.0% - 102.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.