Description

1,4-Pregnadien-11-Beta, 18,21-Diol-3,20-Dione-21 Acetate is a high-purity synthetic steroid intermediate of significant importance in pharmaceutical research and development. This compound serves as a critical precursor in the synthesis of more complex corticosteroid derivatives, enabling the production of potent anti-inflammatory and immunosuppressive agents. It is primarily required by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers focused on advanced steroid chemistry and novel drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent glucocorticoid drugs.
• Corticosteroid Research: Used in academic and industrial research to study structure-activity relationships (SAR) of steroid hormones.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical analysis.
• Process Development: Employed in the development and scale-up of manufacturing processes for steroid-based APIs (Active Pharmaceutical Ingredients).
• Fine Chemical Synthesis: Utilized in custom synthesis projects to create novel steroid analogs for biological testing.

Basic Information

Product Name	1,4-Pregnadien-11-Beta, 18,21-Diol-3,20-Dione-21 Acetate
CAS No.	58761-40-3
Molecular Formula	C23H30O6
Molecular Weight	402.48 g/mol
Synonyms	21-Acetoxyprednisolone; 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate; Prednisolone 21-acetate; 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate; NSC 10483; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate; 21-Acetoxy-11β,17α-dihydroxypregna-1,4-diene-3,20-dione
EINECS	Contact for details

Quality Control

Our 1,4-Pregnadien-11-Beta, 18,21-Diol-3,20-Dione-21 Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.