Description

Pregna-1,4-Diene-3,20-Dione, 21-(Acetyloxy)-9,11-Epoxy-16,17-Dihydroxy-, (9β,11β,16α)- is a high-purity synthetic steroid derivative, specifically a halogenated corticosteroid intermediate. This compound is critical for its role as a key building block in the synthesis of advanced pharmaceutical active ingredients. It is primarily required by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for developing novel anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potent topical and systemic corticosteroids.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new steroid-based drugs.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Process Chemistry: Employed in scale-up and optimization of API (Active Pharmaceutical Ingredient) manufacturing processes under GMP conditions.

Basic Information

Item	Details
Product Name	Pregna-1,4-Diene-3,20-Dione, 21-(Acetyloxy)-9,11-Epoxy-16,17-Dihydroxy-, (9β,11β,16α)-
CAS No.	58404-37-8
Molecular Formula	C23H28O8
Molecular Weight	432.47 g/mol
Synonyms	9,11-Epoxy-16,17-Dihydroxy-21-acetoxypregna-1,4-diene-3,20-dione; 21-Acetoxy-9,11-epoxy-16,17-dihydroxypregna-1,4-diene-3,20-dione; Halometasone Intermediate; 9β,11β-Epoxy-16α,17-dihydroxy-21-acetoxypregna-1,4-diene-3,20-dione; (9β,11β,16α)-21-(Acetyloxy)-9,11-epoxy-16,17-dihydroxypregna-1,4-diene-3,20-dione; Halometasone Acetate Related Compound; Corticosteroid Synthon A
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione, 21-(Acetyloxy)-9,11-Epoxy-16,17-Dihydroxy-, (9β,11β,16α)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Long-term storage under inert atmosphere is recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.