Description

2-Bromo-6Beta,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate) is a high-purity, synthetic steroid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for synthesizing novel corticosteroid analogs with potent anti-inflammatory and immunosuppressive activities. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing next-generation therapeutic agents for dermatological, respiratory, and ophthalmic conditions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel halogenated corticosteroid drugs.
• Research & Development: Used in medicinal chemistry programs to study structure-activity relationships (SAR) of steroid-based therapeutics.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Dermatology Drug Development: Precursor for potent topical corticosteroids used to treat psoriasis, eczema, and dermatitis.
• Anti-inflammatory Agent Synthesis: Core structure for developing agents targeting inflammatory pathways with enhanced potency and selectivity.

Basic Information

Item	Detail
Product Name	2-Bromo-6Beta,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate)
CAS No.	57781-14-3
Molecular Formula	C₂₅H₂₈BrFO₇
Molecular Weight	539.39 g/mol
Synonyms	9α-Fluoro-11β,17α,21-Trihydroxy-2-bromo-16β-methylpregna-1,4-diene-3,20-dione 17,21-Diacetate; 2-Bromo-9α-fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-diacetate; 2-Bromobetamethasone 17,21-diacetate; Halogenated Corticosteroid Intermediate; Betamethasone Derivative
EINECS	Contact for details

Quality Control

Our 2-Bromo-6Beta,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.