Description

(R)-Bufuralol Hydrochloride is a high-purity chiral compound and a selective β-adrenergic receptor antagonist. This material is of significant value in pharmaceutical research and development, particularly for studying stereoselective metabolism and pharmacokinetics. It serves as a critical reference standard and intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in drug substance and product testing.
• Metabolic Studies: A key substrate for investigating cytochrome P450-mediated metabolism, specifically CYP2D6 enzyme activity and polymorphism.
• Pharmacological Research: Employed in preclinical studies to understand the stereospecific effects and binding affinity of β-blockers.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a chiral building block in the synthesis of more complex therapeutic agents.
• Academic Research: Utilized in university and institutional labs for biochemical and pharmacological experiments.

Basic Information

Product Name	(R)-Bufuralol Hydrochloride
CAS No.	57704-11-7
Molecular Formula	C16H23NO2 • HCl
Molecular Weight	297.82 g/mol
Synonyms	(R)-1-(2-(1,1-Dimethylethylamino)-1-hydroxyethyl)-7-ethyl-1H-indole hydrochloride; (R)-1-(2-(tert-Butylamino)-1-hydroxyethyl)-7-ethylindole hydrochloride; (R)-Bufuralol HCl; Dextro-Bufuralol Hydrochloride; (R)-Tertatolol Impurity; CYP2D6 Probe Substrate
EINECS	Contact for details

Quality Control

Our (R)-Bufuralol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing specifications for identity, purity, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R)-enantiomer
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.