Description

(S)-Bufuralol Hydrochloride CAS NO 57704-10-6 is a high-purity, single-enantiomer compound belonging to the class of β-adrenergic receptor antagonists. This chiral specificity is critical for research and development in pharmacology, where the (S)-enantiomer often exhibits distinct biological activity. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and chemical manufacturers engaged in the synthesis of advanced intermediates, method development, and metabolic studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for quality control and assay validation in drug manufacturing and regulatory submissions.
• Metabolite and Impurity Profiling: Used in the identification and quantification of metabolites and related substances during drug development and stability testing.
• Biochemical Research: Employed as a selective tool compound in studies investigating β-adrenergic receptor mechanisms and signal transduction pathways.
• Chiral Synthesis Intermediate: Acts as a key building block for the synthesis of more complex, enantiomerically pure pharmaceutical agents.
• Analytical Method Development: Essential for developing and calibrating chromatographic methods (HPLC, LC-MS) for enantiomeric separation and analysis.

Basic Information

Product Name	(S)-Bufuralol Hydrochloride
CAS No.	57704-10-6
Molecular Formula	C16H23NO2 • HCl
Molecular Weight	313.82 g/mol
Synonyms	(S)-1-(2-(1,1-Dimethylethylamino)-1-hydroxyethyl)-7-ethyl-1H-indole hydrochloride; (S)-1-(2-(tert-Butylamino)-1-hydroxyethyl)-7-ethylindole hydrochloride; (S)-7-Ethylbufuralol hydrochloride; Levobufuralol hydrochloride; Bufuralol (S)-enantiomer hydrochloride; Bufuralol HCl (S-form); (S)-α-[(tert-Butylamino)methyl]-7-ethyl-1H-indole-1-ethanol hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Bufuralol Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for research and development use. A Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.