Description

Aclacinomycin B is a potent anthracycline antibiotic isolated from *Streptomyces galilaeus*. This compound is of significant interest in pharmaceutical research and development due to its established antitumor and antimicrobial activities. It serves as a critical reference standard and a key intermediate for researchers and manufacturers in the oncology and infectious disease sectors, particularly for studying DNA intercalation and topoisomerase inhibition.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of anthracycline antibiotics in research and quality control laboratories.
• Anticancer Research: Investigated as a lead compound or biochemical tool in preclinical studies for its mechanism of action against various cancer cell lines.
• Antimicrobial Agent Development: Serves as a starting point for the synthesis of novel antibiotics targeting drug-resistant bacterial strains.
• Biochemical Studies: Employed in studies of nucleic acid interactions, enzyme inhibition (e.g., topoisomerases), and apoptosis pathways.
• Semi-synthesis Intermediate: Used as a precursor for the chemical modification and development of new anthracycline derivatives with improved efficacy or reduced toxicity.

Basic Information

Product Name	Aclacinomycin B
CAS No.	57596-79-9
Molecular Formula	C₄₂H₅₃NO₁₅
Molecular Weight	811.87 g/mol
Synonyms	Aclarubicin B; ACM-B; Antibiotic MA 144 B1; Aclacinomycin B; (1R,2R,4S)-4-[(2R,4S,5S,6S)-4-(Dimethylamino)-5-[(2S,3S,4S,6R)-3-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-1-naphthacenecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Aclacinomycin B is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Single Maximum Impurity	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.