Description

Aclarubicin is a potent anthracycline antibiotic and antineoplastic agent, primarily recognized for its use in biochemical research and pharmaceutical development. Its core value lies in its mechanism of action, which involves intercalation into DNA and inhibition of topoisomerase II, making it a compound of significant interest for studying cancer therapeutics. This product is essential for research institutions, pharmaceutical R&D departments, and fine chemical suppliers focused on oncology drug discovery and development. We supply high-purity Aclarubicin CAS NO 57576-44-0 to support critical research and manufacturing processes globally.

Application

• Pharmaceutical Intermediate: Serves as a key starting material or intermediate in the synthesis of advanced anticancer agents and novel drug formulations.
• Biochemical Research: Used as a reference standard and active compound in in vitro and in vivo studies to investigate mechanisms of cytotoxicity, DNA damage, and apoptosis.
• Oncology Drug Discovery: A critical tool for screening and developing new chemotherapeutic regimens and combination therapies targeting various cancer cell lines.
• Academic Research: Employed in university and institutional labs for fundamental studies on anthracycline pharmacology, resistance mechanisms, and cardiotoxicity.
• Reference Standard: Provides a high-purity benchmark for quality control and analytical method development in pharmaceutical manufacturing.

Basic Information

Product Name	Aclarubicin
CAS No.	57576-44-0
Molecular Formula	C42H53NO15
Molecular Weight	811.87 g/mol
Synonyms	Aclacinomycin A; Aclacinomycin; Aclacinon; Aclarubicin hydrochloride; ACM-A; Antibiotic MA 144A1; NSC 208734; 2-Ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-1-naphthacenecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Aclarubicin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identity confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.