Description

Cortisol 17-Valerate is a synthetic corticosteroid ester, specifically the 17-valerate derivative of cortisol (hydrocortisone). This chemical modification enhances its lipophilicity and influences its pharmacological profile, making it a valuable intermediate in advanced pharmaceutical synthesis. It is primarily utilized by research institutions and pharmaceutical manufacturers developing topical anti-inflammatory and dermatological products.

Application

• Pharmaceutical Intermediate: Key starting material (KSM) or advanced intermediate in the synthesis of potent topical corticosteroids.
• Research & Development: Used in preclinical and clinical research to study steroid metabolism, receptor binding, and prodrug strategies.
• Dermatological Formulations: Serves as a precursor for active pharmaceutical ingredients (APIs) in creams, ointments, and lotions for treating eczema, psoriasis, and dermatitis.
• Reference Standard: Employed as an analytical standard in quality control laboratories for HPLC, LC-MS, or GC-MS method development and validation.
• Process Chemistry: Used in scale-up and process optimization for the commercial manufacturing of steroid-based therapeutics.

Basic Information

Product Name	Cortisol 17-Valerate
CAS No.	57524-89-7
Molecular Formula	C26H38O6
Molecular Weight	446.58 g/mol
Synonyms	Hydrocortisone 17-Valerate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 17-valerate; 17α-Hydroxycorticosterone 17-valerate; Cortisol 17-valeric acid ester; (11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione 17-valerate
EINECS	Contact for details

Quality Control

Our Cortisol 17-Valerate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.