Description

2-Chloro-5-Fluorobenzonitrile is a versatile halogenated benzonitrile derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents, makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorobenzene or chlorobenzonitrile core structure.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides, where the halogenated aromatic ring contributes to biological activity and stability.
• Liquid Crystal Materials: Serves as a starting material for the synthesis of fluorinated liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the research and production of organic semiconductors and other electronic materials due to its electron-withdrawing characteristics.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct biaryl systems.
• Chemical Research: Utilized in academic and industrial R&D labs as a standard reagent for exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	2-Chloro-5-Fluorobenzonitrile
CAS No.	57381-56-3
Molecular Formula	C7H3ClFN
Molecular Weight	155.56 g/mol
Synonyms	2-Chloro-5-fluorobenzonitrile; 5-Fluoro-2-chlorobenzonitrile; 2-Chloro-5-fluorobenzene carbonitrile; 2-Chloro-5-fluorophenyl cyanide; Benzonitrile, 2-chloro-5-fluoro-; 2-Chloro-5-fluoro-benzonitril; 57381-56-3 (CAS); 2-Cl-5-F-Bn
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-Fluorobenzonitrile is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, GC, and NMR analysis, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) documenting purity, identity, and impurity profiles are available upon request. We support cGMP and ISO 9001 compliant production for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	65 - 68 °C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.