Description

4-Chloro-2-Fluorobenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the benzonitrile core, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, anti-cancer agents, and other biologically active heterocycles.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for the synthesis of fluorinated liquid crystal compounds and electron-transport materials used in organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifiers: Employed to introduce fluorine and cyano functional groups into polymer backbones, modifying thermal stability, chemical resistance, and dielectric properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl systems.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and creating compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	4-Chloro-2-Fluorobenzonitrile
CAS No.	57381-51-8
Molecular Formula	C7H3ClFN
Molecular Weight	155.56 g/mol
Synonyms	2-Fluoro-4-chlorobenzonitrile; 4-Chloro-2-fluorobenzene carbonitrile; 2-Fluoro-4-chlorobenzene carbonitrile; 4-Chloro-2-fluorophenyl cyanide; Benzonitrile, 4-chloro-2-fluoro-; 4-Chloro-2-fluoro-benzonitrile; 57381-51-8; 4-Chloro-2-fluorobenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	65 - 68 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.