Description

2-Bromo-5-Fluorobenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its core value proposition lies in its dual functionalization, providing reactive handles for cross-coupling and nucleophilic substitution reactions, which is critical for constructing complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated and brominated aromatic systems for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides, where the fluorine and bromine substituents contribute to efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as semiconductors and liquid crystals, due to its electron-withdrawing nitrile group and halogen atoms.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form biaryl and other complex structures.
• Nucleophilic Aromatic Substitution: The fluorine atom at the *ortho* position to the nitrile group is activated, allowing for selective substitution with various nucleophiles.

Basic Information

Product Name	2-Bromo-5-Fluorobenzonitrile
CAS No.	57381-39-2
Molecular Formula	C7H3BrFN
Molecular Weight	200.01 g/mol
Synonyms	5-Fluoro-2-bromobenzonitrile; 2-Bromo-5-fluorobenzene carbonitrile; 2-Bromo-5-fluorophenyl cyanide; Benzonitrile, 2-bromo-5-fluoro-; 5-Fluoro-2-bromobenznitrile; 2-Bromo-5-fluorobenzonitrile (major); 57381-39-2 (CAS); 2-Br-5-F-PhCN
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluorobenzonitrile is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity and purity while monitoring for specified impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.