Description

5-Chloro-2-Fluorobenzonitrile is a versatile fluorinated aromatic nitrile building block essential for advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the benzonitrile core, makes it a critical intermediate for introducing specific functional groups and modifying electronic properties in target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides where the chloro-fluoro substitution pattern enhances biological activity and stability.
• Ligand and Material Science: Serves as a starting material for constructing complex ligands in catalysis and for developing advanced organic electronic materials.
• Fluorination Chemistry: Acts as a stable substrate for further functionalization via nucleophilic aromatic substitution (SNAr) reactions, leveraging the activated fluorine atom.
• Cross-Coupling Reactions: The nitrile and halogen groups make it suitable for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to build complex biaryl systems.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic pathways and creating compound libraries for screening.

Basic Information

Product Name	5-Chloro-2-Fluorobenzonitrile
CAS No.	57381-34-7
Molecular Formula	C7H3ClFN
Molecular Weight	155.56 g/mol
Synonyms	2-Fluoro-5-chlorobenzonitrile; 5-Chloro-2-fluorobenzene carbonitrile; 2-Fluoro-5-chlorobenzene nitrile; Benzonitrile, 5-chloro-2-fluoro-; 5-Chloro-2-fluorophenyl cyanide; 57381-34-7 (CAS); 5-Chloro-2-fluoro benzonitrile
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2-Fluorobenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR is supplied with each shipment to guarantee traceability and consistency for your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and reducing agents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	65 - 69 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.