Description

6Alpha,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-(Dihydrogen Phosphate) is a high-purity synthetic corticosteroid phosphate ester, a key pharmaceutical intermediate. Its primary value lies in its role as a water-soluble prodrug for potent anti-inflammatory agents, enabling advanced formulation development. This compound is essential for research and manufacturing in the pharmaceutical industry, particularly for developing injectable and topical corticosteroid therapies targeting severe inflammation and autoimmune conditions.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of advanced corticosteroid drugs like difluprednate.
• Anti-inflammatory Drug Development: Used in R&D for creating novel ophthalmic solutions and topical formulations.
• Prodrug Synthesis: Serves as a phosphate ester prodrug to enhance the solubility and bioavailability of active corticosteroid molecules.
• Reference Standard: Employed as a certified reference material (CRM) for quality control and analytical method validation in pharmaceutical labs.
• Biochemical Research: Used in studies investigating glucocorticoid receptor activity and steroid metabolism pathways.
• Veterinary Medicine: Potential application in developing anti-inflammatory treatments for animals.

Basic Information

Product Name	6Alpha,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-(Dihydrogen Phosphate)
CAS No.	57331-14-3
Molecular Formula	C21H28FO8P
Molecular Weight	458.42 g/mol
Synonyms	Difluprednate Impurity; Difluprednate Related Compound A; 6α,9-Difluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate); 21-Phosphatedifluprednate; Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-, 21-(dihydrogen phosphate), (6α,11β)-; 6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-phosphate; Cortisol 21-phosphate derivative
EINECS	Contact for details

Quality Control

Our 6Alpha,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-(Dihydrogen Phosphate) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and related substances, to ensure it meets exacting standards suitable for pharmaceutical R&D and intermediate use. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.