Description

4-(Difluoromethoxy)-1-Fluoro-2-Nitro-Benzene is a high-purity fluorinated aromatic nitro compound, serving as a critical building block in advanced organic synthesis. Its unique difluoromethoxy and nitro substituents make it a versatile intermediate for constructing complex molecules with tailored properties. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the difluoromethoxy group can improve efficacy and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Liquid Crystal & Dye Chemistry: Acts as a fluorinated building block for synthesizing compounds with specific optical and electronic properties.
• Cross-Coupling Reactions: The nitro and halogen groups make it a suitable substrate for various palladium-catalyzed coupling reactions to create biaryl structures.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-(Difluoromethoxy)-1-Fluoro-2-Nitro-Benzene
CAS No.	57213-30-6
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	1-Fluoro-4-(difluoromethoxy)-2-nitrobenzene; 2-Nitro-4-(difluoromethoxy)fluorobenzene; 4-(Difluoromethoxy)-2-nitrofluorobenzene; Benzene, 1-fluoro-4-(difluoromethoxy)-2-nitro-; 57213-30-6; 1-Fluoro-2-nitro-4-(difluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-1-Fluoro-2-Nitro-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.